ApoE and Inflammation

Apolipoprotein E deposition and astrogliosis are associated with maturation of beta-amyloid plaques in betaAPPswe transgenic mouse: Implications for the pathogenesis of Alzheimer’s disease. Terai, K., Iwai, A., Kawabata, S., Sasamata, M., Miyata, K., & Yamaguchi, T. (2001).  Brain research900(1), 4856.

APOE genotype alters glial activation and loss of synaptic markers in mice. Zhu, Y., Nwabuisi-Heath, E., Dumanis, S. B., Tai, L. M., Yu, C., Rebeck, G. W., & LaDu, M. J. (2012).  Glia60(4), 559569.

Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer’s disease. Yin, Z., Raj, D., Saiepour, N., Van Dam, D., Brouwer, N., Holtman, I. R., Eggen, B., Möller, T., Tamm, J. A., Abdourahman, A., Hol, E. M., Kamphuis, W., Bayer, T. A., De Deyn, P. P., & Boddeke, E. (2017).  Neurobiology of aging55, 115122.

ApoE facilitates the microglial response to amyloid plaque pathology. Ulrich, J. D., Ulland, T. K., Mahan, T. E., Nyström, S., Nilsson, K. P., Song, W. M., Zhou, Y., Reinartz, M., Choi, S., Jiang, H., Stewart, F. R., Anderson, E., Wang, Y., Colonna, M., & Holtzman, D. M. (2018).  The Journal of experimental medicine215(4), 10471058.

Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model. Shi, Y., Manis, M., Long, J., Wang, K., Sullivan, P. M., Remolina Serrano, J., Hoyle, R., & Holtzman, D. M. (2019).  The Journal of experimental medicine216(11), 25462561.

Quantitative proteomics of acutely-isolated mouse microglia identifies novel immune Alzheimer’s disease-related proteins. Rangaraju S, Dammer EB, Raza SA, Gao T, Xiao H, Betarbet R, Duong DM, Webster JA, Hales CM, Lah JJ, Levey AI, Seyfried NT.  Mol Neurodegener. 2018 Jun 28;13(1):34.

Synergistic effects of APOE and sex on the gut microbiome of young EFAD transgenic mice. Maldonado Weng J, Parikh I, Naqib A, York J, Green SJ, Estus S, LaDu MJ.  Mol Neurodegener. 2019 Dec 20;14(1):47.

Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model. Wang H, Li Y, Ryder JW, Hole JT, Ebert PJ, Airey DC, Qian HR, Logsdon B, Fisher A, Ahmed Z, Murray TK, Cavallini A, Bose S, Eastwood BJ, Collier DA, Dage JL, Miller BB, Merchant KM, O’Neill MJ, Demattos RB. Mol Neurodegener. 2018 Dec 17;13(1):65.