ApoE and Aging

Relationship between ApoE, MRI findings, and cognitive function in the Cardiovascular Health Study. Kuller, L. H., Shemanski, L., Manolio, T., Haan, M., Fried, L., Bryan, N., Burke, G. L., Tracy, R., & Bhadelia, R. (1998).  Stroke29(2), 388398.

ApoE plasma levels and risk of cardiovascular mortality in old age. Mooijaart, S. P., Berbée, J. F., van Heemst, D., Havekes, L. M., de Craen, A. J., Slagboom, P. E., Rensen, P. C., & Westendorp, R. G. (2006).  PLoS medicine3(6), e176.

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer’s pathology and APOE genotype. Simpson, J. E., Ince, P. G., Shaw, P. J., Heath, P. R., Raman, R., Garwood, C. J., Gelsthorpe, C., Baxter, L., Forster, G., Matthews, F. E., Brayne, C., Wharton, S. B., & MRC Cognitive Function and Ageing Neuropathology Study Group (2011).  Neurobiology of aging32(10), 17951807.

A reduced astrocyte response to β-amyloid plaques in the ageing brain associates with cognitive impairment. Mathur, R., Ince, P. G., Minett, T., Garwood, C. J., Shaw, P. J., Matthews, F. E., Brayne, C., Simpson, J. E., Wharton, S. B., & MRC Cognitive Function and Ageing Neuropathology Study Group (2015).  PloS one10(2).

Longitudinal and nonlinear relations of dietary and Serum cholesterol in midlife with cognitive decline: results from EMCOA study. An Y, Zhang X, Wang Y, Wang Y, Liu W, Wang T, Qin Z, Xiao R.  Mol Neurodegener. 2019 Dec 30;14(1):51.

Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain. Felsky D, Patrick E, Schneider JA, Mostafavi S, Gaiteri C, Patsopoulos N, Bennett DA, De Jager PL.  Mol Neurodegener. 2018 Jul 24;13(1):38.

ApoE4 attenuates cortical neuronal activity in young behaving apoE4 rats. Har-Paz I, Arieli E, Moran A. Neurobiol Dis. 2021 Jul;155:105373. doi: 10.1016/j.nbd.2021.105373. Epub 2021 Apr 28. PMID: 33932558.

APOE E2/E2 Is Associated with Slower Rate of Cognitive Decline with Age. Sweigart B, Andersen SL, Gurinovich A, Cosentino S, Schupf N, Perls TT, Sebastiani P. J Alzheimers Dis. 2021;83(2):853-860. doi: 10.3233/JAD-201205.