ApoE and α-synuclein

A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides. Gallardo, G., Schlüter, O. M., & Südhof, T. C. (2008).  Nature neuroscience11(3), 301308.

α-Synuclein Interacts with Lipoproteins in Plasma. Emamzadeh, F. N., & Allsop, D. (2017).  Journal of molecular neuroscience : MN63(2), 165172.

Multiple system atrophy and apolipoprotein E. Ogaki, K., Martens, Y. A., Heckman, M. G., Koga, S., Labbé, C., Lorenzo-Betancor, O., Wernick, A. I., Walton, R. L., Soto, A. I., Vargas, E. R., Nielsen, H. M., Fujioka, S., Kanekiyo, T., Uitti, R. J., van Gerpen, J. A., Cheshire, W. P., Wszolek, Z. K., Low, P. A., Singer, W., Dickson, D. W., Ross, O. A. (2018).  Movement disorders : official journal of the Movement Disorder Society33(4), 647650.

α-synuclein-lipoprotein interactions and elevated ApoE level in cerebrospinal fluid from Parkinson’s disease patients. Paslawski, W., Zareba-Paslawska, J., Zhang, X., Hölzl, K., Wadensten, H., Shariatgorji, M., Janelidze, S., Hansson, O., Forsgren, L., Andrén, P. E., & Svenningsson, P. (2019).  Proceedings of the National Academy of Sciences of the United States of America116(30), 1522615235. 

APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid. Zhao, N., Attrebi, O. N., Ren, Y., Qiao, W., Sonustun, B., Martens, Y. A., Meneses, A. D., Li, F., Shue, F., Zheng, J., Van Ingelgom, A. J., Davis, M. D., Kurti, A., Knight, J. A., Linares, C., Chen, Y., Delenclos, M., Liu, C. C., Fryer, J. D., Asmann, Y. W., Bu, G. (2020).  Science translational medicine12(529). 

APOE genotype regulates pathology and disease progression in synucleinopathy. Davis, A. A., Inman, C. E., Wargel, Z. M., Dube, U., Freeberg, B. M., Galluppi, A., Haines, J. N., Dhavale, D. D., Miller, R., Choudhury, F. A., Sullivan, P. M., Cruchaga, C., Perlmutter, J. S., Ulrich, J. D., Benitez, B. A., Kotzbauer, P. T., & Holtzman, D. M. (2020).  Science translational medicine12(529).