Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer’s disease.
Wang N, Pan Y, Starling SC, Haskell DH, Quintero AC, Kawatani K, Inoue Y, Shue F, Ma X, Aikawa T, Martens YA, Kurti A, Parsons TM, Perkerson RB, Roy B, Raulin AC, Ren Y, DeTure M, Dickson DW, Bao H, Han X, Bu G, Kanekiyo T. Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer’s disease. Alzheimers Dement. 2025 Mar;21(3):e70112. doi: 10.1002/alz.70112. PMID: 40145325; PMCID: PMC11947734.
Brain-targeting liposome-based APOE2 gene delivery exacerbates soluble amyloid-? accumulation in AppNL-G-F mice
Wang N, Parsons TM, Ren Y, Pan Y, Kurti A, Starling SC, Muolokwu C, Singh J, Kanekiyo T. Brain-targeting liposome-based APOE2 gene delivery exacerbates soluble amyloid-? accumulation in AppNL-G-F mice. Heliyon. 2024 Oct 18;10(20):e39607. doi: 10.1016/j.heliyon.2024.e39607. PMID: 39506961; PMCID: PMC11538761.
Alzheimer’s disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice
Ma X, Prokopenko D, Wang N, Aikawa T, Choi Y, Zhang C, Lei D, Ren Y, Kawatani K, Starling SC, Perkerson RB, Roy B, Quintero AC, Parsons TM, Pan Y, Li Z, Wang M, Bao H, Han X, Bu G, Tanzi RE, Kanekiyo T. Alzheimer’s disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice. Neurobiol Dis. 2025 Mar;206:106813. doi: 10.1016/j.nbd.2025.106813. Epub 2025 Jan 27. PMID: 39880319; PMCID: PMC11884743.