To request tissues
Dominantly Inherited Alzheimer Network (DIA) The Dominantly Inherited Alzheimer Network (DIAN) Observational Study enables researchers around the world to monitor and identify changes in individuals who carry one of the gene mutations (Presenilin1, Presenilin2 or APP) known to cause dominantly inherited Alzheimer’s disease (DIAD).
Tauopathies: The tauopathy cell bank represents cells from individuals with genetic causes of primary tauopathy (e.g. MAPT mutations), those with a clinical or neuropathologic diagnosis for primary tauopathy (PSP, CBD, or FTD), and controls. Cell lines were generated as part of a collaborative effort supported by the Tau Consortium, Washington University Knight ADRC, University of California San Francisco Memory and Aging Clinic, and NeuraCell.
Knight ADRC: A biorepository that represents a genetically defined and ancestrally diverse collection of human somatic and stem cell models. Cells can be evaluated based on rare variants, polygenic risk score for AD, FTD or PD, or clinical and fluid/imaging biomarker status at biopsy collection.
fibroblasts, iPSC, and isogenic cell lines are available from mutation carriers and related non-carriers
Fibroblasts, iPSC, and isogenic cell lines are available
fibroblasts, iPSC, isogenic, and engineered (Ngn2, CRISPRi) cell lines are available
Karch Lab: https://karchlab.wustl.edu/projects/project-1-amyloid-dominantly-inherited-alzheimer-network/ · DIAN: https://dian.wustl.edu/our-research/for-investigators/
Karch Lab: https://karchlab.wustl.edu/resources/ipsc-biomarker-core/· Tau Consortium/Neuracell: https://www.neuracell.org/cell-supply/stem-cells
Karch Lab: https://karchlab.wustl.edu/projects/knight-alzheimer-disease-research-center-biomarker-core/