Biology and pathobiology of apoE in aging and Alzheimer’s disease
The overarching theme of this U19 project is to understand the biology and pathobiology of apolipoprotein E whose gene represents the strongest genetic risk factor for Alzheimers disease and several other aging related conditions. The U19 will take advantage of the strengths and existing synergy among its multidisciplinary and multi-institutional investigators to elucidate how apolipoprotein E isoforms have profound effects on functional outcomes at the molecular, cellular, and systems levels, and how these pathways can be targeted for therapy. This U19 project will also engage the broader scientific community by sharing knowledge, resources, and data through a web portal and by promoting collaboration through an annual ApoE Symposium.
ApoE Cascade Hypothesis (c)
- Administrative Core (Core A)
- Biochemistry and Structural Modeling Core (Core B)
- Neuropathology Core (Core C)
- Biomarker Core (Core D)
- Human iPSC Models Core (Core E)
- Multi-Omics Core (Core F)
- Bioinformatics, Biostatistics, and Data Management Core (Core G)
- Project 1: ApoE isoform-specific structure: insights on biology and pathobiology
- Project 2: APOE effects on glial lipid metabolism and 25-hydroxcholesterol: Effects on aging and AD-related pathology
- Project 3: Astrocytic and microglial apoE in aging and AD
- Project 4: Impact of vascular apoE in aging and AD
- Project 5: Genetic modifiers of APOE-related risk for AD