Gene Expresssion Database

**Alzheimers risk factors age, APOE genotype, and sex drive distinct molecular pathways**

Zhao N, Ren Y, Yamazaki Y, Qiao W, Li F, Felton L, Mahmoudiandehkordi S, Kueider-Paisley A, Sonoustoun B, Arnold M, Shue F, Zheng J, Attrebi O, Martens Y, Li Z, Bastea L, Meneses A, Chen K, Thompson J, St. John-Williams L, Tachibana M, Aikawa T, Oue H, Job L, Yamazaki A, Liu C-C, Storz P, Asmann Y, Ertekin-Taner N, Kanekiyo T, Kaddurah-Daouk R, and Bu G . Neuron, Mar 2020.

Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer's disease.

Wang N, Pan Y, Starling SC, Haskell DH, Quintero AC, Kawatani K, Inoue Y, Shue F, Ma X, Aikawa T, Martens YA. Alzheimer's & Dementia, 2025 Mar;21(3):e70112

Brain-targeting liposome-based APOE2 gene delivery exacerbates soluble amyloid-? accumulation in App^NL-G-F mice

Wang N, Parsons TM, Ren Y, Pan Y, Kurti A, Starling SC, Muolokwu C, Singh J, Kanekiyo T. Heliyon. 2024 Oct 30;10(20).

Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice

Ma X, Prokopenko D, Wang N, Aikawa T, Choi Y, Zhang C, Lei D, Ren Y, Kawatani K, Starling SC, Perkerson RB. Neurobiology of Disease. 2025 Jan 27:106813.

Bulk RNA-seq dataset of human APOE-TR mice from three sources (Taconic Biosciences, Cure Alzheimer’s Fund, and The Jackson Laboratory)

Wang N, etc