ApoE and TREM2
Variant of TREM2 associated with the risk of Alzheimer’s disease. Jonsson, T., Stefansson, H., Steinberg, S., Jonsdottir, I., Jonsson, P. V., Snaedal, J., Bjornsson, S., Huttenlocher, J., Levey, A. I., Lah, J. J., Rujescu, D., Hampel, H., Giegling, I., Andreassen, O. A., Engedal, K., Ulstein, I., Djurovic, S., Ibrahim-Verbaas, C., Hofman, A., Ikram, M. A., Stefansson, K. (2013). The New England journal of medicine, 368(2), 107116.
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques. Wang, Y., Ulland, T. K., Ulrich, J. D., Song, W., Tzaferis, J. A., Hole, J. T., Yuan, P., Mahan, T. E., Shi, Y., Gilfillan, S., Cella, M., Grutzendler, J., DeMattos, R. B., Cirrito, J. R., Holtzman, D. M., & Colonna, M. (2016). The Journal of experimental medicine, 213(5), 667675.
The Alzheimer’s disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway. Jendresen, C., Ã…rskog, V., Daws, M. R., & Nilsson, L. N. (2017). Journal of neuroinflammation, 14(1), 59.
TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway. Zheng, H., Jia, L., Liu, C. C., Rong, Z., Zhong, L., Yang, L., Chen, X. F., Fryer, J. D., Wang, X., Zhang, Y. W., Xu, H., & Bu, G. (2017). The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(7), 17721784.
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases. Krasemann, S., Madore, C., Cialic, R., Baufeld, C., Calcagno, N., El Fatimy, R., Beckers, L., O’Loughlin, E., Xu, Y., Fanek, Z., Greco, D. J., Smith, S. T., Tweet, G., Humulock, Z., Zrzavy, T., Conde-Sanroman, P., Gacias, M., Weng, Z., Chen, H., Tjon, E., Butovsky, O. (2017). Immunity, 47(3), 566581.
High-affinity interactions and signal transduction between Aβ oligomers and TREM2. Lessard, C. B., Malnik, S. L., Zhou, Y., Ladd, T. B., Cruz, P. E., Ran, Y., Mahan, T. E., Chakrabaty, P., Holtzman, D. M., Ulrich, J. D., Colonna, M., & Golde, T. E. (2018). EMBO molecular medicine, 10(11), e9027.
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE. Parhizkar, S., Arzberger, T., Brendel, M., Kleinberger, G., Deussing, M., Focke, C., Nuscher, B., Xiong, M., Ghasemigharagoz, A., Katzmarski, N., Krasemann, S., Lichtenthaler, S. F., Müller, S. A., Colombo, A., Monasor, L. S., Tahirovic, S., Herms, J., Willem, M., Pettkus, N., Butovsky, O., Haass, C. (2019). Nature neuroscience, 22(2), 191204.
Soluble TREM2 induces inflammatory responses and enhances microglial survival. Zhong, L., Chen, X. F., Wang, T., Wang, Z., Liao, C., Wang, Z., Huang, R., Wang, D., Li, X., Wu, L., Jia, L., Zheng, H., Painter, M., Atagi, Y., Liu, C. C., Zhang, Y. W., Fryer, J. D., Xu, H., & Bu, G. (2017). The Journal of experimental medicine, 214(3), 597607.
Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). Atagi, Y., Liu, C. C., Painter, M. M., Chen, X. F., Verbeeck, C., Zheng, H., Li, X., Rademakers, R., Kang, S. S., Xu, H., Younkin, S., Das, P., Fryer, J. D., & Bu, G. (2015). The Journal of biological chemistry, 290(43), 2604326050.
New insights into the role of TREM2 in Alzheimer’s disease. Gratuze M, Leyns CEG, Holtzman DM. Mol Neurodegener. 2018 Dec 20;13(1):66.
